张玉珍
发布时间：2016-06-22 11:53:50
点击次数：3895
张玉珍，博士，教授、博士生导师，同济大学心律失常教育部重点实验室、同济大学东方转化医学研究中心（东方医院）PI。1996年毕业于上海第二医科大学，获心血管博士学位。2000 年起在美国宾州大学心血管系进行博士后研究，主要从事脂质代谢和动脉粥样硬化的研究，文章以第一作者发表在《 Circulation》、《 J Clin Invest》 上；以后成为高级科学研究员从事心肺发育、基因调控、细胞重新编程(cell reprogram)和干细胞(stem cell research)等研究，以第一作者在《 Nat Genet》、《 Genes & Dev》和《 Development》等国际著名杂志发表文章，以合著者发表《 Cell Stem Cell》封面文章。 自 2012 年 2 月全职回国任同济大学附属东方医院转化中心、心律失常教育部重点实验室课题组长、研究员、教授、博士生导师，主要研究方向血管损伤修复、动脉粥样硬化等血管病变形成发展；高血压、冠心病心肌重构的分子生物学机制研究。
一、代表性论文
Pi J1#, Tao T1#, Zhuang T1#, Sun H1, Chen X1, Liu J1, Cheng Y1, Yu Z1, Zhu HH1, Gao WQ1, Suo Y1, Wei X1, Chan P1, Zheng X1,Tian Y1, Morrisey E1, Zhang L1*, Zhang Y2*. A MicroRNA302- 367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability. Circ Res. 2017 Jan 6; 120(1):85-98.
Kuang Y1#, Li X1#, Chen X1#, Sun H1, Tomlinson B2, Chan P3, Zheng L1, Pi J1, Peng S1, Wu H4, Ding X4, Qian D4, Shen Y1, Yu Z1, Fan L1,Chen M1, Fan H1, Liu Z1*, Zhang Y1*. Higher prevalence of elevated LDL-C than non-HDL-C and low statin treatment rate in elderly community-dwelling Chinese with high cardiovascular risk. Sci Rep. 2016 Sep 30;6:34268. doi: 10.1038/srep34268.
Fan H#, Li X#, Zheng L#, Chen X, Lan Q, Wu H, Ding X, Qian D, Shen Y, Yu Z, Fan L, Chen M, Tomlinson B, Chan P, Zhang Y*, Liu Z*. Abdominal obesity is strongly associated with Cardiovascular Disease and its Risk Factors in Elderly and very Elderly Community-dwelling Chinese. Sci Rep. 2016 Feb 17; 6:21521. doi: 10.1038/srep21521.
Peng S1, Shen T1, Liu J1, Tomlinson B2, Sun H1, Chen X1, Paul Chan3, Kuang Y1, Zheng L1, Wu H4, Ding X4, Qian D4, Shen Y1, Gao P5, Fan H1, Liu Z1, Zhang Y1. Uncontrolled Hypertension Increases with Age in an Older Community-Dwelling Chinese Population in Shanghai, accepted by Aging and Disease 2017 Oct, 8 (5)
Zhang Y, McGillicuddy FC, Hinkle CC, O'Neill S, Glick JM, Rothblat GH, Reilly MP. Adipocyte modulation of high-density lipoprotein cholesterol. Circulation 2010 Mar; 121(11): 1347-55.
Zhang Y, Li S, Yuan A, Tian Y, Yang J, Liu F, Chokas A, Morrisey. Foxp1 coordinates cardiomyocyte proliferation through both cell autonomous and non-autonomous mechanisms. Genes & Dev 2010 Aug; 24(16):1746-57
Zhang Y, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo FJ, Whitsett JA, Parmacek MS, Morrisey EE. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 2008 Jul;40(7):862-70.
Zhang Y, Da Silva JR, Reilly M, Billheimer JT, Rothblat GH, Rader DJ. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest. 2005 Oct;115(10):2870-4
Zhang YZ, Zanotti I, Reilly M; Glick J M, Rothblat G H, and Rader D J. Overexpression of apoA-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation 2003 Aug 12;108(6):661-3.
Tomlinson B1,2, Hu M2, Zhang Y1, Chan P3, Liu ZM4. Liraglutide for weight management: benefits and risks. Curr Med Res Opin. 2017 Mar;33(3):537-539. doi: 10.1080/03007995.2016.1271315
Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM. Effects of glucose-lowering drugs on cardiovascular outcomes in patients with type 2 diabetes. Expert Opin Drug Metab Toxicol. 2016 Sep 19:1-5.
Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM. An overview of new GLP-1 receptor agonists for type 2 diabetes. Expert Opin Investig Drugs. 2016 Feb;25(2):145-58.
Deng S1,2, Zhao Q3, Zhou X4, Zhang L5, Bao L6, Zhen L7, Zhang Y8, Fan H9, Liu Z10, Yu Z11. Neonatal Heart-Enriched miR-708 Promotes Differentiation of Cardiac Progenitor Cells in Rats. Int J Mol Sci. 2016 Jun 7;17(6).
Liang D, Li J, Wu Yahan, Zhen LX, Li CM, Qi M, Wang LJ, Deng F, Huang J, Lv F, Liu Y, Ma XE, Yu ZR, Zhang YZ, Chen YH. miRNA-204 drives cardiomyocyte Proliferation via targeting Jarid2. Int J Cardiol. 2015; 201: 38-48.
Zheng L, Lan Q, Zhang Y, Feng J, Wang G, Li X, Kang S, Li J, Fan H, Liu Z. The screening value of baPWV and hs-crp to ASCVD in middle and elderly community population in Shanghai. Int J Cardiol. 2015;186:289-90.
Liang D, Xu X, Deng F, Feng J, Zhang H, Liu Y, Zhang Y, Pan L, Liu Y, Zhang D, Li J, Liang X, Sun Y, Xiao J, Chen YH. miRNA-940 reduction contributes to human Tetralogy of Fallot development. J Cell Mol Med. 2014; 18(9): 1830-1839.
Shi D, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias. J Cell Mol Med. 2014; 18(10): 1992-1999.
Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A, Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun. 2013;4:2812. (Co-author)
Li J, Xu L, Ye J, Li X, Zhang D, Liang D, Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y, Zhang Y, Zhou Z, Liang X, Li J, Peng L, Zhu W, Chen YH. Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis. J Cell Mol Med. 2013; 17(9): 1119-1127.
Li S, Wang Y, Zhang Y, Lu MM, DeMayo FJ, Dekker JD, Tucker PW, Morrisey EE. Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul;139(14):2500-9.
Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011 Apr;138(7):1235-45.
Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, and Morrisey EE. Highly efficient miRNA mediated reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 2011 April; 8:376–388.
二、基金项目
1. 国家自然科学基金重大研究计划培育项目，91639112，Foxp1介导IL-b/Lox-1调节内皮细胞/单核巨噬细胞交互作用 在动脉粥样硬化发生发展中的作用 2017/01-2019/12，直接费用 65万，在研，主持
2. 国家重点基础研究计划--973项目，2014CB965100，人胚胎干细胞衍生细胞治疗心肌梗死后心力衰竭的关键科学问题研究(多模态评估临床前hESCs衍生细胞移植安全性、有效性和功能整合，2014/01-2018/08，60万，在研，骨干
3. 国家重点基础研究计划--973项目，2012CB966800，“干细胞分裂模式和干细胞干性维持的机制研究”之分课题“miRNA和蛋白质修饰在干细胞对称/不对称分裂过程中的作用及机理”，2012/01-2016/08，300万，已结题，课题组长
4. 国家自然科学基金面上项目，81170116，“Gata6对血管损伤修复和动脉粥样硬化形成的作用及其机制”，2012/01-2015/12，52万，已结题，主持
5.上海市浦江人才计划，13PJ1407000，“Foxp1调控巨噬细胞极性/可塑性与动脉粥样硬化的形成发展”，2013/01-2015/01，20万，已结题，主持
6. 国际重大合作交流项目，81120108004，“心脏离子通道蛋白胞膜定向运输机制研究”，2012/01-2016/12，260万，在研，参加
7. 国家创新研究群体科学基金项目，81221001，“心律失常发生机制研究”，2013/01- 2015/12，600万，已结题，参加
三、荣誉与奖项
2014年11月获得上海市科学技术二等奖。
2014年10月获得上海市浦东新区科学技术一等奖。